An USPTO Patent Granted To Mesoblast Limited For The Treatment Of Heart Diseases, Stroke And Other Vascular Conditions

November 24, 2015by Yamini Asthana0

mesoblast-medicineUnited States Patent and Trademark Office (USPTO) has granted a key patent to Mesoblast Limited (ASX:MSB) (USOTC:MBLTY) casing employment of the Company’s proprietary adult Mesenchymal Precursor Cells (MPCs) for the formation and repair of blood vessels in ischemic tissues. The announcement about the recent patent grant was made on Oct. 27th 2015. Mesoblast Limited is an Australian-based regenerative medicine company, which hunts for providing treatments for inflammatory ailments, cardiovascular disease and back pain. The company is headed by founder, Silviu Itescu, who founded the company in 2004.

US Patent No. 9,169,466 entitled ‘Perivascular Mesenchymal Precursor Cell Induced Blood Vessel Formation’ affords commercial rights in the United States up to 8th January 2025 in line with adjustments. Furthermore, auxiliary patent term extension might transpire along with regulatory exclusivity extensions. The granted claims envelop the use of the Company’s allogeneic or off-the-shelf MPCs acquired from any source in conditions including ischemic heart disease, stroke and peripheral arterial disease. Mesoblast’s allogeneic, ‘off-the-shelf’ cell product candidates are significantly suitable and targeted for diseases which are in very advanced stages along with highly unmet medical needs; the conditions include cardiovascular conditions, orthopedic disorders, immunologic/inflammatory disorders and oncology/hematology conditions. The company is developing a range of regenerative products derived from its proprietary mesenchymal lineage cells, which includes Mesenchymal Precursor Cells (MPCs) and Mesenchymal Stem Cells (MSCs).

Mesoblast enjoys the patent legacy as the company has also been previously granted patents in Europe (EP1613335) and Japan (2006-503990) originating from the same patent family thus benefiting from exclusive commercial rights in the two other major healthcare markets to a minimum of 29 March 2024. The company has more than 661 patents or patent applications across no less than 72 patent families, thus affording considerable spirited advantages for the commercial development of cellular therapeutic products based on mesenchymal lineage cells. The prior granted patents include US7514074, US7892829, US8158120, US8158121, US8852570, US8852571, US8852572, US8852573, US8852574 and US8852575. They deal with allogeneic culture-expanded Mesenchymal Stem Cell product candidates for cardiovascular diseases.

The major thrust areas of Research and Development of Mesoblast includes:
1. Immunologic and inflammatory – IV administration of cells to impart immuno-modulatory effects.
2. Cardiac and vascular – Local administration of cells to improve heart anatomy and function.
3. Orthopedic diseases of the spine – Local administration of cells for potential repairmen of intervertebral discs or regeneration of bone.
4. Oncology – Improving outcomes of bone marrow transplantation in patients with cancer or genetic diseases.

Few milestones achieved by Mesoblast are:
> December 2010 – agreement with US-based Cephalon to develop and commercialize novel adult Mesenchymal Precursor Stem Cell (MPC) therapeutics for degenerative conditions of the cardiovascular and central nervous systems.
> September 2011 – agreement with Swiss-based Lonza Group that Lonza will manufacture the stem cells in sufficient quantity to meet the global demand for Mesoblast’s MPC cell products and Mesoblast will also have exclusive access to Lonza’s Cell Therapy facilities in Singapore for the manufacture of allogeneic cell therapy, subject to certain exceptions.
> October 2013 – Mesoblast acquired the entire culture-expanded mesenchymal stem cell (MSC) business of Osiris Therapeutics. Mesoblast also inherited a relationship with Japan-based JCR Pharmaceuticals Co. Ltd.
> May 2014 – Mesoblast announced about receiving incentives from the Singapore Economic Development Board (EDB) for activities in Singapore related to manufacturing operations, as well as product development and commercialization.
> June 2015 – Mesoblast received $5.8 million from the Australian Government for Research & Development (R&D) activities.

Yamini Asthana

Yamini Asthana

Dr. Yamini Asthana, with an academic background in biochemistry and research expertise in the fields of inorganic biochemistry and material sciences, is the technology specialist for biochemical and pharmaceutical inventions. She herself is an inventor for an US patent in the field of nanotechnology.

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